The Importance and Differences Between Vitamin K2 MK-7 and K2 MK-4

Vitamin K, a family of vitamins, (just like the B vitamins) that are related compounds vital for health. There are two forms: menaquinone-4 (MK-4) and menaquinone-7 (MK-7). These two forms, although similar in their basic function, have significant differences in their efficacy, bioavailability, and health benefits.

The Basics of Vitamin K2

Vitamin K2 is part of the Vitamin K group, which plays a crucial role in blood clotting, bone health and more. It's classified into different types based on the length of their molecular side chains, with MK-4 and MK-7 being the most prominent forms.

MK-4: Characteristics and Uses

MK-4, found in animal products like meat, eggs, and dairy, is known for its potential in treating specific conditions such as myelodysplasia, hepatocellular carcinoma, and possibly osteoporosi. It is often used in higher doses compared to MK-7, with typical dosages around 45 mg/day, which is significantly higher than the dosages used for MK-7 in osteoporosis studies (180–375 µg/day).

MK-7: Superior Bioavailability and Effects

On the other hand, MK-7, primarily found in fermented foods like natto, is more potent and has a longer half-life than MK-4. This means it remains effective in the body for a more extended period. A key study showed that MK-7, when administered daily, resulted in a steady-state plasma vitamin K concentration five times higher than that achieved by an equivalent amount of Vitamin K1. This form of Vitamin K2 is particularly beneficial for cardiovascular health and has been shown to improve arterial health by preventing calcification and inflammation. K2 has even been shown to reverse existing calcification and restore flexibility and elasticity to vessels.

Health Benefits

Both MK-4 and MK-7 contribute significantly to maintaining bone health. MK-7, in particular, is associated with increased bone mineral density and improved bone quality and strength. MK-7 has also shown promising results in addressing a range of health issues like osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer’s disease, diabetes, and peripheral neuropathy.

The Study Findings

Recent clinical trials have highlighted the benefits of Vitamin K2, especially MK-7. For instance, a study by Knapen et al. showed that daily intake of MK-7 (180 μg) by healthy post-menopausal women led to substantial cardiovascular benefits. In comparison, MK-4 has relatively poor bioavailability at a nutritional level dose, whereas MK-7 is well absorbed and detectable in the blood at nutritional level.

Nutritional Sources and Recommendations

The dietary intake of Vitamin K2, particularly MK-4 and MK-7, is primarily through cheese, egg yolks, butter, meats, and natto. While leafy green vegetables are the main source of Vitamin K1, foods like soybean and canola oil also contribute to the intake of this vitamin

The Synergistic Power of Vitamin K2 with Vitamin D3

This dynamic duo works together to enhance each other's effects, particularly in bone health and cardiovascular wellness. Vitamin D3 is essential for calcium absorption in the gut, but it's Vitamin K2, like MK-7 and MK-4, that help direct this calcium to where it's needed most - in bones and teeth, rather than allowing it to deposit in arteries and soft tissues. This partnership not only maximizes the benefits of each vitamin but also plays a critical role in preventing conditions such as osteoporosis and arterial calcification. Incorporating both these vitamins into your diet or supplementation regime can lead to a more balanced and effective approach to maintaining bone density and cardiovascular health.

Conclusion

In conclusion, while both MK-4 and MK-7 are beneficial forms of Vitamin K2, MK-7 stands out due to its higher potency, longer half-life, and better bioavailability. But Mk-4 also has strong cancer prevention properties, it just needs to be taken 2 or 3 times a day as opposed to just once a day with Mk7. These properties make it particularly effective in improving cardiovascular health and bone density. As research continues to evolve, the understanding and application of these forms of Vitamin K2 will undoubtedly expand, offering more targeted and effective ways to utilize these vital nutrients.